ICD-10-CM > R00-R99 > R50-R69 > R65 > R65.1 R65.1 Systemic inflammatory response syndrome (SIRS) of non-infectious origin Non-Billable/Non-Specific Code First underlying condition, such as:heatstroke (T67.0-)injury and trauma (S00-T88) Type 1 Excludes sepsis- code to infectionsevere sepsis (R65.2) Codes R65.10Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunctionR65.11Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction