ICD-10-CM > R00-R99 > R50-R69 > R65 R65 Symptoms and signs specifically associated with systemic inflammation and infection Non-Billable/Non-Specific Codes R65.1Systemic inflammatory response syndrome (SIRS) of non-infectious originR65.10Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunctionR65.11Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunctionR65.2Severe sepsisR65.20Severe sepsis without septic shockR65.21Severe sepsis with septic shock